At the heart of the European Union, ONE’s Brussels team is on a mission: to unlock economic opportunity and champion global health across Africa. We don’t just watch policy happen, we shape it. By engaging directly with EU and national decision-makers, we turn political processes into platforms for justice.
Our priorities:

Protecting the EU’s Global Impact
We fight to safeguard and strengthen the EU’s external action budget. From the high-stakes Multiannual Financial Framework (MFF) negotiations to annual budget processes, we ensure the EU’s resources match its global ambition.

Leading on Global Health
We push the EU to remain a world leader in saving lives. We advocate for bold, commitments to powerhouses like Gavi, the Vaccine Alliance, and the Global Fund to Fight AIDS, Tuberculosis and Malaria, ensuring the fight against preventable diseases stays at the top of the agenda.

A New Africa-Europe Partnership
We are calling on leaders to scrap the outdated status quo. We demand a partnership built on a new foundation of equity, shared ambition, and opportunity for all.
Powered by people
Change does not happen behind closed doors alone. It happens when people demand it. Our team works hand-in-hand with partners and stakeholders across the EU, fueled by our flagship network:
ONE Youth Ambassadors
Every year, over 100 Youth Ambassadors from across Belgium, Italy, France, Germany and the Netherlands join our movement. They are part of a global force of 1,000+ advocates across Africa, Europe, and North America. These activists don’t just volunteer, they amplify. They engage directly with policymakers, lead public actions, and create the creative content that makes our message unmissable.
Our Supporters
Beyond our formal networks, thousands of supporters across the EU add their voices at critical moments. They turn public pressure into political will by contacting decision-makers, signing open letters, and mobilizing during legislative milestones.