Our priorities:

Protecting the EU’s Global Impact
We fight to safeguard and strengthen the EU’s external action budget. From the high-stakes Multiannual Financial Framework (MFF) negotiations to annual budget processes, we ensure the EU’s resources match its global ambition.

Leading on Global Health
We push the EU to remain a world leader in saving lives. We advocate for bold, commitments to powerhouses like Gavi, the Vaccine Alliance, and the Global Fund to Fight AIDS, Tuberculosis and Malaria, ensuring the fight against preventable diseases stays at the top of the agenda.

A New Africa-Europe Partnership
We are calling on leaders to scrap the outdated status quo. We demand a partnership built on a new foundation of equity, shared ambition, and opportunity for all.
We work with EU institutions and national governments to push for policies and investments that strengthen global health and economic opportunity across Africa. Whether it’s a high-level European Council summit, a razor-thin vote in Parliament, or new legislative proposal from the European Commission, ONE shows up. Persistent. United. Focused on impact. We ensure that the fight for a fairer, healthier world is a political priority.
Powered by people
Change happens when people raise their voices together. Every year, more than 100 ONE Youth Ambassadors across Europe join a global network of 1000+ advocates driving action on global health and economic opportunity. From meeting policymakers to leading campaigns and public actions, they help push these issues higher up the political agenda.
Explore the latest from ONE in Brussels:

Cameroon is more than the story you think you know

Africa Day: “Young Africans are not asking for charity”
Meet the Brussels team
As a co-founding member of the MFF Hub, we work alongside more than 100 civil society organizations to advocate for an ambitious EU budget that invests in global development, humanitarian action and climate.
If you believe everyone deserves the opportunity to live a healthy, dignified life, no matter where they live, join ONE and help push EU leaders to act for a more equitable future.










