An unlikely public health hero: TB-detecting giant rats
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An unlikely public health hero: TB-detecting giant rats

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Yes, you read that right: rats. To most people, the sight of a giant rat is disgusting. But for many scientists, these rats are extremely helpful.

One in three people are currently living with tuberculosis, according to the Stop TB Partnership. That’s almost 2 billion people worldwide. Tuberculosis is a leading cause of death by infectious disease, and existing systems that work to detect it lack accuracy, time efficiency, and cost efficiency. Because of this, people in regions like East Africa often don’t undergo screening to detect the disease—due to lack of awareness or money—and many cases go undetected. In places like jails, where TB is estimated to be ten times more prevalent, this issue is much worse.

Enter super-rat:

African rats are being trained by a Belgium nongovernmental organization to detect TB within minutes in prisons in Tanzania and Mozambique!

Malagasy_Giant_Rat_(Hypogeomys_antimena)

Photo credit: Wikimedia Commons

How, you ask?

Here’s where it gets really interesting. When these rats reach four weeks of age, they begin a rigorous training process. They are introduced to different stimuli and are trained to interact with humans. They are taught to recognize the presence of TB in human mucus. (And you thought the rats were gross!)

The rats are presented with ten samples of this mucus, or sputum, and when they detect the ones with TB, they hover over them for three seconds to let the scientist know what they have smelled and are then rewarded when they succeed. How AMAZING is that?!

Perhaps even more incredible is their success rate and the speed at which they can detect TB. These rats can detect tuberculosis with almost 100 percent accuracyThe rats are cost effective and once trained they can screen around 100 samples in 20 minutes. While a scientist would require a day to determine the presence of TB in a patient, this rat can take a mere seven minutes.

Lab_mouse_mg_3263

Photo credit: Wikimedia Commons

This new method of screening for TB has HUGE implications for developing countries that are heavily burdened by tuberculosis. With funding from USAID (United States Aid in International Development), APOPO plans to recruit and train more of these rats to screen in prisons. 

Thank you, giant rats! We’ll try to think nicer thoughts when we see you around.

Help us encourage world leaders to give to the Global Fund so it can officially end TB as a threat to public health by 2030: Tell world leaders to support the Global Fund today!

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